In-Laboratory High-Dose Clopidogrel Loading
نویسندگان
چکیده
منابع مشابه
Effect on platelet reactivity from a prasugrel loading dose after a clopidogrel loading dose compared with a prasugrel loading dose alone: Transferring From Clopidogrel Loading Dose to Prasugrel Loading Dose in Acute Coronary Syndrome Patients (TRIPLET): a randomized controlled trial.
BACKGROUND Adding a prasugrel loading dose (LD) to a clopidogrel LD could be desirable because clopidogrel may fail to provide adequate levels of platelet inhibition in patients with acute coronary syndrome undergoing percutaneous coronary intervention. METHODS AND RESULTS The pharmacodynamic response of prasugrel 60 mg ld alone was compared with prasugrel 60 mg or 30 mg added 24 hours to clo...
متن کاملEffects of high loading dose of clopidogrel in ST elevated myocardial infarction treated with fibrinolytic agent.
PURPOSE The purpose of the present study was to evaluate the effects of different loading doses of clopidogrel on ST segment resolution on ECG, changes in cardiac enzyme levels and serum levels of high-sensitivity C-reactive protein (Hs-CRP) in patients with ST elevated myocardial infarction (STEMI) treated with fibrinolytic therapy. METHODS Patients admitted to our cardiology clinic with a d...
متن کاملHigh clopidogrel loading dose during coronary stenting: effects on drug response and interindividual variability.
AIM To assess platelet inhibitory effects, interindividual variability in platelet inhibition as well as response to a 600 mg, compared to a standard 300 mg, clopidogrel loading dose (LD) after coronary stenting METHODS AND RESULTS Platelet function profiles were assessed in 50 patients undergoing coronary stenting receiving either a 300 mg (n=27) or 600 mg clopidogrel LD. ADP (6 microM) and ...
متن کاملAdjunctive Cilostazol versus High Maintenance Dose of Clopidogrel in Patients with Hyporesponsiveness to Chronic Clopidogrel Therapy
PURPOSE Whether addition of cilostazol is superior to increasing dose of clopidogrel in patients with hyporesponsiveness to chronic clopidogrel therapy is unknown. MATERIALS AND METHODS We studied 73 patients with hyporesponsiveness to clopidogrel on standard dual antiplatelet therapy for more than 2 weeks. Clopidogrel hyporesponsiveness was defined as percent inhibition of P2Y12 reaction uni...
متن کاملRethinking loading dose clopidogrel in light of increased bleeding complications in bypass patients.
he recent paper by Berger et al. (1) brings to light an important point hat we think affects a majority of cardiologists and cardiac surgeons like. The use of clopidogrel is now widespread, and the American ollege of Cardiology/American Heart Association (ACC/AHA) uidelines (2) highlight the indications for its use. However, more ften we anecdotally observe indiscriminate use of loading dose lo...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2010
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2010.01.068